Natural Cycle IVF

Natural IVF and Natural Modified IVF is an individualized IVF treatment plan based on each woman’s hormonal levels during her natural menstrual cycle. The treatment protocol varies depending on the age, the needs and the cycle in which the woman decides to start her treatment. Comparing the natural selection of the oocytes (eggs) with the conventional IVF protocols there is a significant advantage of better-quality oocytes as they are not “bombarded” with high doses of ovarian stimulating hormones but constitute the natural choice from the ovarian “deposit”. The modern woman spends less creative time, as the treatment is time- and cost-effective and it can be repeated safely every month without the required “rest” period of the ovaries as there is no risk of ovarian hyperstimulation.

Natural IVF

Nature’s advantages

  • Development of high-quality embryos is increased significantly (Kollmann et al. 2017).
  • Enhancement of the endometrium receptivity as there is no external effect on gene expression at cellular level during the development of the endometrium since there is no or limited administration of hormones (Horcajadas et al. 2008, von Wolff M et al. 2014).
  • Safe process without the risk of ovarian hyperstimulation and long-term impact to the woman’s health
  • Possibility for repeated cycles every month as it is not necessary a ‘rest’ period for the ovaries


The natural IVF is the best choice for women with:

  • poor ovarian response
  • poor egg quality
  • perimenopausal women
  • medical history of malignancy
  • high risk of developing ovarian overstimulation syndrome
  • repeated IVF failures using stimulation
  • reluctance to undergo injectable treatments

The natural IVF protocol requires close monitoring by a qualified physician, due to the complexity of hormonal fluctuations and the experience required in order to collect as many ovarian follicles as possible with the less intervention and the specific ability to obtain the oocytes during the egg retrieval procedure.

Do not hesitate to contact with the specialized obstetrician-gynecologist in IVF, Dr. Melina Stasinou ( for a personalized diagnosis and advice on your individualized natural protocol.